Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

An unexpected role for IL-17 in lymphoid organogenesis

In response to inhaled pathogens, lymphoid tissues can form in the lung. The driving force behind this organogenic process turns out to be interleukin 17–mediated activation of lung stromal cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Organogenic functions of lymphotoxin and IL-17.

Katie Vicari

References

  1. van de Pavert, S.A. & Mebius, R.E. Nat. Rev. Immunol. 10, 664–674 (2010).

    Article  CAS  Google Scholar 

  2. Randall, T.D. Adv. Immunol. 107, 187–241 (2010).

    Article  CAS  Google Scholar 

  3. Rangel-Moreno, J. et al. Nat. Immunol. 12, 639–646 (2011).

    Article  CAS  Google Scholar 

  4. Cupedo, T. et al. Nat. Immunol. 10, 66–74 (2009).

    Article  CAS  Google Scholar 

  5. Mebius, R.E., Rennert, P. & Weissman, I.L. Immunity 7, 493–504 (1997).

    Article  CAS  Google Scholar 

  6. Eberl, G. et al. Nat. Immunol. 5, 64–73 (2004).

    Article  CAS  Google Scholar 

  7. Yokota, Y. et al. Nature 397, 702–706 (1999).

    Article  CAS  Google Scholar 

  8. De Togni, P. et al. Science 264, 703–707 (1994).

    Article  CAS  Google Scholar 

  9. Harmsen, A. et al. J. Immunol. 168, 986–990 (2002).

    Article  CAS  Google Scholar 

  10. Fukuyama, S. et al. Immunity 17, 31–40 (2002).

    Article  CAS  Google Scholar 

  11. Iwakura, Y., Ishigame, H., Saijo, S. & Nakae, S. Immunity 34, 149–162 (2011).

    Article  CAS  Google Scholar 

  12. Gaboriau-Routhiau, V. et al. Immunity 31, 677–689 (2009).

    Article  CAS  Google Scholar 

  13. Lotz, M. et al. J. Exp. Med. 203, 973–984 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tom Cupedo.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cupedo, T. An unexpected role for IL-17 in lymphoid organogenesis. Nat Immunol 12, 590–592 (2011). https://doi.org/10.1038/ni.2058

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2058

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing