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A WNK in the kidney controls blood pressure

Nature Genetics volume 38, pages 1105–1106 (2006)Cite this article

Precise control of sodium excretion by the kidney is critical for maintaining fluid and electrolyte homeostasis. A new mouse model provides compelling evidence that a kinase, WNK4, provides key signals for regulating blood pressure and potassium balance by controlling the structure and function of the distal convoluted tubule.

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Figure 1: Schematic depicting the sodium-chloride cotransporter (NCC), the potassium channel (ROMK), the sodium channel (ENaC), WNK1 and WNK4 in a renal epithelial cell in the latter portion of the distal convoluted tubule.

Kim Caesar

References

  1. Guyton, A.C. Science 252, 1813–1816 (1991).

    Article  CAS  Google Scholar 

  2. Lifton, R.P., Gharavi, A.G. & Geller, D.S. Cell 104, 545–556 (2001).

    Article  CAS  Google Scholar 

  3. Lalioti, M.D. et al. Nat. Genet. 38, 1124–1132 (2006).

    Article  CAS  Google Scholar 

  4. Hadchouel, J., Delaloy, C., Faure, S., Achard, J.M. & Jeunemaitre, X. J. Am. Soc. Nephrol. 17, 208–217 (2006).

    Article  CAS  Google Scholar 

  5. Wilson, F.H. et al. Science 293, 1107–1112 (2001).

    Article  CAS  Google Scholar 

  6. Xu, B.E. et al. Cell Res. 15, 6–10 (2005).

    Article  Google Scholar 

  7. Monroy, A., Plata, C., Hebert, S.C. & Gamba, G. Am. J. Physiol. Renal Physiol. 279, F161–F169 (2000).

    Article  CAS  Google Scholar 

  8. Wilson, F.H. et al. Proc. Natl. Acad. Sci. USA 100, 680–684 (2003).

    Article  CAS  Google Scholar 

  9. Yang, C.L., Angell, J., Mitchell, R. & Ellison, D.H. J. Clin. Invest. 111, 1039–1045 (2003).

    Article  CAS  Google Scholar 

  10. Yang, C.L., Zhu, X., Wang, Z., Subramanya, A.R. & Ellison, D.H. J. Clin. Invest. 115, 1379–1387 (2005).

    Article  CAS  Google Scholar 

  11. Fuller, P.J. & Young, M.J. Hypertension 46, 1227–1235 (2005).

    Article  CAS  Google Scholar 

  12. Robert-Nicoud, M. et al. Proc. Natl. Acad. Sci. USA 98, 2712–2716 (2001).

    Article  CAS  Google Scholar 

  13. Crowley, S.D. et al. J. Clin. Invest. 115, 1092–1099 (2005).

    Article  CAS  Google Scholar 

  14. Levy, D. et al. Hypertension 36, 477–483 (2000).

    Article  CAS  Google Scholar 

  15. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. JAMA 288, 2981–2997 (2002).

Download references

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  1. Division of Nephrology, Department of Medicine, Duke University and the Durham Veterans Administration Medical Centers, Durham, 27710, North Carolina, USA

    Thomas M Coffman

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  1. Thomas M Coffman
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Coffman, T. A WNK in the kidney controls blood pressure. Nat Genet 38, 1105–1106 (2006). https://doi.org/10.1038/ng1006-1105

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