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Microsatellite mapping of a gene affecting horn development in Bos taurus

Nature Genetics volume 4, pages 206–210 (1993)Cite this article

Abstract

The presence or absence of horns in Bos taurus is thought to be under the genetic control of the autosomal polled locus, characterized by two alleles: P dominant over p, and causing the polled or hornless phenotype. We have demonstrated genetic linkage between the polled locus and two microsatellite markers, GMPOLL–1 and GMPOLL–2, and have assigned the corresponding linkage group to bovine chromosome 1. This confirms the existence of the postulated polled locus and the hypothesized inheritance pattern. It will allow marker assisted selection for the polledness trait in breeding programs and is a first step towards positional cloning and molecular study of a gene that has been subjected to both natural and artificial selection.

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References

  1. Steele, M.R. & Georges, M. Generation of bovine multisite haplotypes using random cosmid clones. Genomics 10, 889–904 (1991).

    Article  CAS  PubMed  Google Scholar 

  2. Georges, M. et al. Characterization of a set of Variable Number of Tandem Repeat markers conserved in Bovidae. Genomics 11, 24–32 (1991).

    Article  CAS  PubMed  Google Scholar 

  3. Georges, M. & Massey, J. Polymorphic DNA markers in Bovidae. International patent application published under the patent cooperation treaty. (No. WO 92/13102. WIPO, Geneva, Switzerland, 1992).

  4. O'Brien, S. Mammalian genome mapping: lessons and prospects. Curr. Op. Genet. Dev. 1, 105–111 (1991).

    Article  CAS  PubMed  Google Scholar 

  5. Soller, M. & Beckman, J.S. Restriction fragment length polymorphisms and genetic improvement. Proceedings of the 2nd World Congress on Genetics Applied to Livestock production 6, 396–404 (Madrid, 1982).

  6. Georges, M. et al. Microsatellite mapping of the gene causing weaver disease in cattle will allow the study of an associated QTL. Proc. natn. Acad. Sci. U.S.A. 90, 1058–1062 (1993).

    Article  CAS  Google Scholar 

  7. Dove, W.F. The physiology of horn growth: a study of the morphogenesis, the interaction of tissues, and the evolutionary processes of a Mendelian recessive character by means of transplantation of tissues. J. exp. Zool. 69, 347–405 (1935).

    Article  Google Scholar 

  8. Bateson, W. & Saunders, E.R. Reports to the Evolutionary Commitee of the Royal Society. 1, (Harrison and Sons, London, 1902).

  9. White, W.T. & Ibsen, H.L. Horn inheritance in Galloway-Holstein cattle crosses. J. Genet. 32, 33–49 (1936).

    Article  Google Scholar 

  10. Long, C.R. & Gregory, K.E. Inheritance of the horned, scurred and polled condition in cattle. J. Hered. 69, 395–400 (1978).

    Article  Google Scholar 

  11. Frisch, J.E., Nishimura, H., Cousins, K.J., Turner, H.G. The inheritance and effect on production of polledness in four crossbred lines of beef cattle. Anim. Prod. 31, 119–126 (1980).

    Article  Google Scholar 

  12. Smith, A.D.B. The inheritance of horns in cattle. Some further data. J. Genet. 18, 365–374 (1927).

    Article  Google Scholar 

  13. Johansson, I. & Rendel, J. Genetics and Animal Breeding. 180–182 (W.H. Freeman, San Francisco, 1968).

  14. Soller, M., Padeh, B., Wysoki, M. & Ayalon, N. Cytogenetics of Saanen goats showing abnormal development of the reproductive tract associated with the dominant gene for polledness. Cytogenetics 8, 51–67 (1969).

    Article  CAS  PubMed  Google Scholar 

  15. Burgoyne, P.S. Genetic homology and crossing over in the X and Y chromosomes of mammals. Hum. Genet. 61, 85–90 (1982).

    Article  CAS  PubMed  Google Scholar 

  16. Dietz, A.B., Neibergs, H.L. & Womack, J.E. Assignment of eight locitobovine syntenic groups by use of PCR: extension of a comparative gene map. Mamm. Genome 3, 106–111 (1992).

    Article  CAS  PubMed  Google Scholar 

  17. O'Brien, S.J. & Marshall Graves, J.A. Report of the committee on comparative gene mapping. Cytogenet. cell. Genet. 58, 1124–1151 (1991).

    Article  Google Scholar 

  18. Bricker, R.A. & Church, R.B. Mapping a polled gene in a 1:29 Robertsonian study in Charolais cattle. Abst. 36th annual meeting of the Genetics Society of Canada (Kingston, Ontario. June 11–14, 1991).

  19. Meischke, H.R.C., Ramsay, W.R. & Shaw, F.D. The effects of horns on bruising in cattle. Aust. Vet. J. 50, 432–434 (1974).

    Article  CAS  PubMed  Google Scholar 

  20. Lathrop, G.M. & Lalouel, J.-M. Easy calculations of lod scores and genetic risks on small computers. Am. J. hum. Genet. 36, 460–465 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Lathrop, G.M., Lalouel, J.M., Julier, C. & Ott, J. Strategies for multilocus linkage analysis in humans. Proc. natn. Acad. Sci. U.S.A. 101, 3443–3446 (1984).

    Article  Google Scholar 

  22. Womack, J.E. & Moll, Y.D. Gene map of the cow: conservation of linkage with mouse and man. J. Hered. 77, 2–7 (1986).

    Article  CAS  PubMed  Google Scholar 

  23. Chevalet, C. & Corpet, F. Statistical decision rules concerning synteny or independence between markers. Cytogenet. Cell Genet. 43, 132–139 (1986).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Genmark Inc, 421 Wakara Way, Salt Lake City, Utah, 84108, USA

    Michel Georges, Anuradha Mishra, Dahlia Nielsen, Leslie S. Sargeant, Anita Sorensen, Michael R. Steele & Xuyun Zhao

  2. CSIRO, Division of Tropical Animal Production, Molecular Animal Genetics Centre, University of Queensland, Brisbane, Queensland, 4072, Australia

    Roger Drinkwater, Tracey King, Stephen S. Moore & Jay Hetzel

  3. Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, 77843-4463, USA

    James E. Womack

Authors
  1. Michel Georges
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  2. Roger Drinkwater
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  3. Tracey King
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  4. Anuradha Mishra
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  5. Stephen S. Moore
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  6. Dahlia Nielsen
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  7. Leslie S. Sargeant
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  8. Anita Sorensen
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  9. Michael R. Steele
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  10. Xuyun Zhao
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  11. James E. Womack
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Georges, M., Drinkwater, R., King, T. et al. Microsatellite mapping of a gene affecting horn development in Bos taurus. Nat Genet 4, 206–210 (1993). https://doi.org/10.1038/ng0693-206

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