Abstract
We report here the comparative DNA sequence analysis of nearly 100 kilobases of contiguous DNA in the Cδ to Cα region of the α/δ T cell receptor loci (TCRAC/TCRDC) of mouse and man. This analysis — the largest genomic sequence comparison so far — provides new insights into the functions of the T cell receptor genes as well as the surrounding chromosome structure through the identification of actively conserved DNA sequences. In this comparison we have identified a very high level of organizational and noncoding sequence similarity (∼71%) in contrast to previous findings in the β–globin gene cluster. This observation begins to question the notion that much of the chromosomal non–coding sequence is junk.
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Koop, B., Hood, L. Striking sequence similarity over almost 100 kilobases of human and mouse T–cell receptor DNA. Nat Genet 7, 48–53 (1994). https://doi.org/10.1038/ng0594-48
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DOI: https://doi.org/10.1038/ng0594-48
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