Three new studies identify nearly 20 new loci for serum lipid levels using predominantly a prospective cohort study design which also permits extensive and unbiased characterization of environmental exposures. Given the known, strong environmental influences on these traits, investigation of gene-environment interactions should be emphasized in attempts to understand the complete epidemiologic and genetic architecture of these complex traits.
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Manolio, T. Cohort studies and the genetics of complex disease. Nat Genet 41, 5–6 (2009). https://doi.org/10.1038/ng0109-5
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DOI: https://doi.org/10.1038/ng0109-5
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