Abstract
The endodermal epithelium of vertebrates generates many types of enteroendocrine cells, including the insulin- and glucagon-secreting cells of the islets of Langerhans. Two studies disclose that Notch signalling controls which cells differentiate as enteroendocrine cells—a finding with implications for therapeutic strategy.
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(Adapted from ref. 16.)
References
Rehfeld, J.F. Physiol. Rev. 78, 1087–1108 (1998).
Jensen, J. et al. Nature Genet. 24, 36– 44 (2000).
Apelqvist, A. et al. Nature 400, 877–881 (1999).
Pearse, A.G.E. J. Histochem. Cytochem. 17, 303–313 (1969).
Cheng, H. & Leblond, C.P. Am. J. Anat. 141, 503–520 (1974).
Fontaine, J. & Le Douarin, N. J. Embryol. Exp. Morphol. 41, 209–222 (1977).
Rawdon, B.B. & Andrew, A. Histol. Histopathol. 8, 567–580 (1993).
Edlund, H. Curr. Opin. Cell Biol. 11, 663–668 (1999).
Naya, F.J. et al. Genes Dev. 11, 2323–2324 (1997).
St-Onge, L., Sosa-Pineda, B., Chowdhury, K., Mansouri, A. & Gruss, P. Nature 387, 406–409 (1997).
Lewis, J. Curr. Opin. Neurobiol. 6, 3–10 (1996).
de la Pompa, J.L. et al. Development 124, 1139– 1148 (1997).
Chitnis, A., Henrique, D., Lewis, J., Ish-Horowicz, D. & Kintner, C. Nature 375, 761– 766 (1995).
Artavanis-Tsakonas, S., Rand, M.D. & Lake, R.J. Science 284, 770– 776 (1999).
Barrett, P. et al. Histochem. J. 27, 482– 486 (1995).
Gray's Anatomy (ed. Williams, P.L.) (Churchill Livingstone, London, 1995).
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Skipper, M., Lewis, J. Getting to the guts of enteroendocrine differentiation. Nat Genet 24, 3–4 (2000). https://doi.org/10.1038/71653
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DOI: https://doi.org/10.1038/71653
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