Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Comparison of evolutionary models for TCGA and simulated data.


  1. 1

    William, M.J., Werner, B., Barnes, C.P., Graham, T.A. & Sottoriva, A. Nat. Genet. 48, 238–244 (2016).

    Article  Google Scholar 

  2. 2

    Cibulskis, K. et al. Nat. Biotechnol. 31, 213–219 (2013).

    CAS  Article  Google Scholar 

  3. 3

    Gerstung, M. et al. Nat. Commun. 3, 811 (2012).

    Article  Google Scholar 

Download references


We would like to thank H.S. Kim for helpful discussions and J. Cha for graphics design. J.H.C. was supported by the National Cancer Institute of the NIH under award R21CA191848 and supplement R21CA191848-01A1S1. Research was also partially supported by the National Cancer Institute under award P30CA034196.

Author information



Corresponding author

Correspondence to Jeffrey H Chuang.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Note

Supplementary Note (DOCX 132 kb)

Supplementary Code

ipython notebook with code used for computations. (TXT 174 kb)

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Noorbakhsh, J., Chuang, J. Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures. Nat Genet 49, 1288–1289 (2017).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing