Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A saltationist theory of cancer evolution

A new study based on single-nucleus sequencing reports that triple-negative breast cancers acquire copy number aberrations in short punctuated bursts in the earliest stages of tumor evolution, rather than continuously and gradually, challenging prevailing models of tumor evolution.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Two models of tumor evolution.

References

  1. Nowell, P.C. Science 194, 23–28 (1976).

    Article  CAS  Google Scholar 

  2. Gao, R. et al. Nat. Genet. 48, 1119–1130 (2016).

    Article  CAS  Google Scholar 

  3. Sottoriva, A. et al. Nat. Genet. 47, 209–216 (2015).

    Article  CAS  Google Scholar 

  4. Ling, S. et al. Proc. Natl. Acad. Sci. USA 112, E6496–E6505 (2015).

    Article  CAS  Google Scholar 

  5. Williams, M.J., Werner, B., Barnes, C.P., Graham, T.A. & Sottoriva, A. Nat. Genet. 48, 238–244 (2016).

    Article  CAS  Google Scholar 

  6. Hicks, J. et al. Genome Res. 16, 1465–1479 (2006).

    Article  CAS  Google Scholar 

  7. Baca, S.C. et al. Cell 153, 666–677 (2013).

    Article  CAS  Google Scholar 

  8. Stephens, P.J. et al. Cell 144, 27–40 (2011).

    Article  CAS  Google Scholar 

  9. Shah, S.P. et al. Nature 486, 395–399 (2012).

    Article  CAS  Google Scholar 

  10. Zhang, C.-Z. et al. Nature 522, 179–184 (2015).

    Article  CAS  Google Scholar 

  11. Garsed, D.W. et al. Cancer Cell 26, 653–667 (2014).

    Article  CAS  Google Scholar 

  12. Eldredge, N. & Gould, S.J. in Models in Paleobiology (ed. Schopf, T.) 82–115 (Freeman, Cooper & Co, 1972).

    Google Scholar 

  13. Goldschmidt, R. The Material Basis of Evolution (Yale University Press, 1940).

    Google Scholar 

  14. Gould, S.J. Nat. Hist. 86, 22–30 (1976).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Florian Markowetz.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Markowetz, F. A saltationist theory of cancer evolution. Nat Genet 48, 1102–1103 (2016). https://doi.org/10.1038/ng.3687

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3687

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer