A hallmark of CpG islands is their unmethylated state, and determining how DNA methylation can invade these elements is therefore important for understanding developmental gene regulation and disease. A new study shows that FBXL10, a protein commonly altered by mutation in leukemia, is part of a mechanism that blocks methylation of CpG islands.
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Kelsey, G. Keeping methylation at bay. Nat Genet 47, 427–428 (2015). https://doi.org/10.1038/ng.3290
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DOI: https://doi.org/10.1038/ng.3290
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