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A developmental program drives aggressive embryonal brain tumors

Embryonal tumors with multilayered rosettes (ETMRs) are primitive neuroectodermal tumors arising in infants. A new study shows that these tumors are universally driven by fusion of the promoter of a gene with brain-specific expression, TTYH1, to C19MC, the largest human microRNA cluster, activating a fetal neural development program.

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Figure 1: A recurrent TTYH1-C19MC fusion drives tumor formation by co-opting a developmental circuit.

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Correspondence to Scott L Pomeroy.

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Archer, T., Pomeroy, S. A developmental program drives aggressive embryonal brain tumors. Nat Genet 46, 2–3 (2014). https://doi.org/10.1038/ng.2857

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