We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10−13; odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10−15; OR = 1.50).
Subscribe to Journal
Get full journal access for 1 year
only $17.42 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Bevier, M., Sundquist, K. & Hemminki, K. Breast Cancer Res. Treat. 132, 723–728 (2012).
Basham, V.M. et al. Breast Cancer Res. 4, R2 (2002).
Thomas, G. et al. Nat. Genet. 41, 579–584 (2009).
Wang, C. et al. Mol. Endocrinol. 25, 1527–1538 (2011).
Orr, N. et al. PLoS Genet. 7, e1002290 (2011).
Meijers-Heijboer, H. et al. Nat. Genet. 31, 55–59 (2002).
Easton, D.F. et al. Nature 447, 1087–1093 (2007).
Haiman, C.A. et al. Nat. Genet. 43, 1210–1214 (2011).
Stevens, K.N. et al. Cancer Res. 72, 1795–1803 (2012).
Fletcher, O. et al. J. Natl. Cancer Inst. 103, 425–435 (2011).
Stacey, S.N. et al. Nat. Genet. 39, 865–869 (2007).
Stacey, S.N. et al. Nat. Genet. 40, 703–706 (2008).
Turnbull, C. et al. Nat. Genet. 42, 504–507 (2010).
Ghoussaini, M. et al. Nat. Genet. 44, 312–318 (2012).
Garcia-Closas, M. et al. PLoS Genet. 4, e1000054 (2008).
We thank the men who participated in the study. For ICR sample collection, we are grateful to B. Smith, D. Hogben, R. McCann, J. Melia, S. Squires, M. Snigorska, J. Micic and K. Sibley for administrative help and advice; to the research nurses A. Butlin, M. Pelerin, J. Wood and T. Gardener for collection of blood samples and questionnaire data from participants; to D. Thomas and her team from the Breakthrough Generations Study for coordinating collection of controls; and to the cancer registries of England and Wales for providing information on eligible participants. The Study of Epidemiology and Risk Factors in Cancer Heredity (SEARCH) thanks the SEARCH team. We wish to thank H. Thorne, E. Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics and the Clinical Follow Up Study (funded from 2001–2009 by the Australian National Health & Medical Research Council (NHMRC) and currently by the National Breast Cancer Foundation and Cancer Australia, 628333) for their contributions to this resource and the many families who contribute to kConFab. We thank G. Wilhoite for preparing the US samples for this study. We thank A. Jukkola-Vuorinen, V. Kataja and P. Auvinen, as well as S. Hallamies and S. Ranta, for their contributions to the Finnish Male Breast Cancer Study. We thank J. Forteza, M. Fraga, C. Celeiro and the staff of the Department of Pathology of CHUS Santiago and A. Carracedo and C.M. Redondo for their contributions to the Spanish study. Finally, we thank the consultants who cared for the study participants for their advice and help. The Breakthrough Male Breast Cancer Study was approved by the South Eastern Research Ethics Committee. Participants gave informed consent for all aspects of the study.
This work was supported by Breakthrough Breast Cancer, Movember and the Institute of Cancer Research who acknowledge National Health Service (NHS) funding to the National Institute for Health Research (NIHR) Biomedical Research Centre. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The High-Throughput Genomics Group at the Wellcome Trust Centre for Human Genetics is funded by Wellcome Trust grant 090532/Z/09/Z and UK Medical Research Council (MRC) Hub grant G0900747 91070. This work made use of data and samples generated by the 1958 British Birth Cohort under grant G0000934 from the UK MRC and grant 068545/Z/02 from the Wellcome Trust. The Finnish Male Breast Cancer Study acknowledges funding from the Finnish Breast Cancer Group, the Finnish Oncology Association and the Salonoja Foundation. L.O. acknowledges funding from the Italian Association for Cancer Research (AIRC, IG 8713). D.P. acknowledges funding from the Istituto Toscano Tumori, Florence, Italy. SEARCH is funded by a grant from Cancer Research UK (C490/A10124) and is supported by the University of Cambridge NIHR Biomedical Research Centre. A.M.D. has been funded by Cancer Research UK grant CA8197/A10865 and by the Joseph Mitchell Fund. D.T.B. acknowledges funding by Cancer Research UK (Programme Award C588/A10589). M.G.-D. and J.E.C. acknowledge the support of the Department of Pathology of the CHUS Santiago Hospital, the Galician Foundation of Genomic Medicine and the Program Grupos Emergentes, Cancer Genetics Unit of CHUVI, Instituto de Salud Carlos III. H.O. and I.H. acknowledge funding from the Swedish Cancer Society and The Swedish Medical Research Council. The collection of samples and epidemiological data for the US cases was supported by US ARMY Grant DAMD-17-96-I-6266 and US National Institutes of Health (NIH) grant R01CA74415. S.L.N. was partially supported by the Morris and Horowitz Families Endowed Professorship at the City of Hope.
The authors declare no competing financial interests.
A list of members and affiliations is provided in the Supplementary Note.
About this article
Cite this article
Orr, N., Lemnrau, A., Cooke, R. et al. Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk. Nat Genet 44, 1182–1184 (2012). https://doi.org/10.1038/ng.2417
Nature Communications (2020)
Kaposi Sarcoma in Association With an Extracavitary Primary Effusion Lymphoma Showing Unusual Intravascular Involvement
The American Journal of Dermatopathology (2020)
JNCI Cancer Spectrum (2020)
International Journal of Cancer (2020)
PLOS Genetics (2019)