Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the β-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for β-defensin genes and risk of psoriasis.
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We would like to thank J. Tyson for help and advice, and J. Hewitt and J. Brookfield for comments on the manuscript. This work was funded by a Wellcome Trust Bioarchaeology Postdoctoral Fellowship awarded to E.J.H. (grant 071024) and a grant from the Genomics Program of the Netherlands Organisation for Scientific Research to J.S. (050-10-102).
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Hollox, E., Huffmeier, U., Zeeuwen, P. et al. Psoriasis is associated with increased β-defensin genomic copy number. Nat Genet 40, 23–25 (2008). https://doi.org/10.1038/ng.2007.48
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