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Psoriasis is associated with increased β-defensin genomic copy number

Abstract

Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the β-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for β-defensin genes and risk of psoriasis.

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Figure 1: Frequency distributions of β-defensin genomic copy number.

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Acknowledgements

We would like to thank J. Tyson for help and advice, and J. Hewitt and J. Brookfield for comments on the manuscript. This work was funded by a Wellcome Trust Bioarchaeology Postdoctoral Fellowship awarded to E.J.H. (grant 071024) and a grant from the Genomics Program of the Netherlands Organisation for Scientific Research to J.S. (050-10-102).

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E.J.H., A.R., J.S. and J.A.L.A. conceived and coordinated the study. P.C.M.v.d.K., H.T., M.d.H., P.L.J.M.Z., D.R.-O., A.R. and J.S. collected and characterized the clinical samples. Copy number typing was carried out by E.J.H. (MAPH/REDVR), R.P., J.A.L.A., J.L. and U.H. (PRT). E.J.H., J.S., J.A.L.A. and G.d.J. performed the statistical and typing quality analysis, with contributions from P.L.J.M.Z., U.H. and M.d.H. All authors contributed to the writing of the paper, with major input from E.J.H., J.S., A.R. and J.A.L.A.

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Correspondence to John A L Armour.

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Hollox, E., Huffmeier, U., Zeeuwen, P. et al. Psoriasis is associated with increased β-defensin genomic copy number. Nat Genet 40, 23–25 (2008). https://doi.org/10.1038/ng.2007.48

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