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Mice with human livers deal with drugs the human way

Nature (2011)Cite this article

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'Humanized' mice could provide better assessment of drugs' toxicity for humans.

The unique physiology of the human liver means that the toxicity of some candidate drugs is not picked up during preclinical tests in animals. But mice implanted with miniature human livers can mimic the ways in which the human body breaks down chemical compounds, to help spot potential problems before drugs are tested in humans.

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References

  1. Chen, A. et al. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.1101791108 (2011).

  2. Dorner, M. et al. Nature 474, 208-211 (2011).

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  1. Marian Turner
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Sangeeta Bhatia and Alice Chen

Alexander Ploss

James Di Santo

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Turner, M. Mice with human livers deal with drugs the human way. Nature (2011). https://doi.org/10.1038/news.2011.409

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  • DOI: https://doi.org/10.1038/news.2011.409

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