AIDS virus thwarts even the best drugs by hiding in the gut.
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References
Chun, T.-W. et al. J. Infect. Dis. doi:10.1086/527324 (2007) [note: not 2008?!].
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Hopkin, M. HIV can 'never be cured'. Nature (2008). https://doi.org/10.1038/news.2008.595
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DOI: https://doi.org/10.1038/news.2008.595