Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Antiviral Activity produced by the Polycytidylic Acid-Hexainosinate System

Nature New Biology volume 234, pages 105–106 (1971)Cite this article

Abstract

Experiments with poly C oligo I indicate that both components are necessary for interferon induction, and that the secondary structure of the polymer is not critical.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Field, A. K., Tyttel, A. A., Lampson, G. P., and Hilleman, M. R., Proc. US Nat. Acad. Sci., 58, 1004 (1967).

    Article  CAS  Google Scholar 

  2. Merigan, T. C., Nature, 228, 219 (1970).

    Article  CAS  Google Scholar 

  3. Baron, S., Bogomolova, N. N., Billiau, A., Levy, H. B., Buckler, C. E., Stern, R., and Naylor, R., Proc. US Nat. Acad. Sci., 64, 67 (1969).

    Article  CAS  Google Scholar 

  4. Billiau, A., Buckler, C. E., Dianzani, F., Uhlendorf, C., and Baron, S., Proc. Soc. Exp. Biol. Med., 132, 790 (1969).

    Article  CAS  Google Scholar 

  5. DeClercq, E., and DeSomer, P., Science, 173, 260 (1971).

    Article  CAS  Google Scholar 

  6. Carter, W. A., Hande, K., Essien, B., and Kaback, M. M., Infection and Immunity, 3, 671 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Pitha, P. M., and Carter, W. A., Virology, 45, 777 (1971).

    Article  CAS  Google Scholar 

  8. Colby, C., and Chamberlin, M. J., Proc. US Nat. Acad. Sci., 63, 160 (1969).

    Article  CAS  Google Scholar 

  9. Michelson, A. M., and Monny, C., Biochim. Biophys. Acta, 149, 107 (1967).

    Article  CAS  Google Scholar 

  10. Pitha, P. M., and Ts'o, P. O. P., Biochemistry, 8, 5206 (1969).

    Article  CAS  Google Scholar 

  11. Carter, W. A., and Pitha, P. M., in Biological Effects of Polynucleotides (edit. by Beers, jun., R. F., and Braun, W.) (Springer, New York, in the press).

  12. Pitha, J., and Pitha, P. M., Science, 172, 1146 (1971).

    Article  CAS  Google Scholar 

  13. Ryser, H. J. P., in Proc. Fourth Intern. Congr. Pharmacology, 3, 96 (Schwabe, Basle and Stuttgart, 1969).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine and Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205

    PAULA M. PITHA & WILLIAM A. CARTER

Authors
  1. PAULA M. PITHA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. WILLIAM A. CARTER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

PITHA, P., CARTER, W. Antiviral Activity produced by the Polycytidylic Acid-Hexainosinate System. Nature New Biology 234, 105–106 (1971). https://doi.org/10.1038/newbio234105a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio234105a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing