Abstract
In the normal XX female, one of the two X chromosomes is inactivated at an early stage in development. This article discusses the current theories proposed to account for X inactivation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Brown, S. W., Science, 151, 417 (1966).
Jones, K. W., Nature, 225, 912 (1970).
Pardue, M. L., and Gall, J. G., Science, 168, 1357 (1970).
Lyon, M. F., Phil. Trans. Roy. Soc., B, 259, 41 (1970).
Chen, S. H., Malcolm, L. A., Yoshida, A., and Gibbett, E. R., Amer. J. Human Genet., 23, 87 (1971).
Cooper, D. W., VandeBerg, J. L., Sharman, G. B., and Poole, W. E., Nature New Biology, 230, 155 (1971).
Romeo, G., and Migeon, B. R., Science, 170, 180 (1970).
Cooper, D. W., Nature, 230, 292 (1971).
Grumbach, M. M., Morishima, A., and Taylor, J. H., Proc. US Nat. Acad. Sci., 49, 581 (1963).
Cattanach, B. M., Perez, J. N., and Pollard, C. E., Genet. Res., 15, 183 (1970).
Russell, L. B., Science, 140, 976 (1963).
Eicher, E., Adv. Genet., 15, 175 (1971).
Comings, D. E., Amer. J. Human Genet., 20, 440 (1968).
Britten, R. J., and Davidson, E. H., Science, 165, 349 (1969).
Arrighi, F. E., Hsu, T. C., Saunders, P., and Saunders, G. F., Chromosoma, 32, 224 (1970).
Ris, H., and Kubai, D. F., Ann. Rev. Genet., 4, 263 (1970).
Pallotta, D., Berlowitz, L., and Rodriguez, L., Exp. Cell. Res., 60, 474 (1970).
Gianelli, F., Monographs in Human Genetics, 5: Human Chromosomes DNA Synthesis (Karger, Basel, 1970).
Ohno, S., Ann. Rev. Genet., 3, 495 (1969).
Epstein, C. J., Science, 163, 1078 (1969).
Monesi, V., Chromosoma, 17, 11 (1965).
Lee, J. C., and Yunis, J. J., Chromosoma, 32, 237 (1971).
Hill, R. N., and Yunis, J. J., Science, 155, 1120 (1967).
Brinster, R. L., Biochem. Genet., 4, 669 (1970).
Daentl, D. L., and Epstein, C. J., Amer. J. Human Genet., 22, 41a (1970).
Axelson, M., Hereditas, 60, 347 (1968).
Issa, M., Blank, C. E., and Atherton, G. W., Cytogenetics, 8, 219 (1969).
Gardner, R. L., and Lyon, M. F., Nature, 231, 385 (1971).
Ellem, K. A. O., and Gwatkin, R. B. L., Develop. Biol., 18, 311 (1968).
Sabour, M., quoted by Chandra, H. S., Genet. Res. (in the press).
Klinger, H. P., Kosseff, A., and Plotnick, F., Adv. Biosci., 6, 207 (1971).
Gurdon, J. B., Proc. Roy. Soc., B, 176, 303 (1970).
Schindler, A. M., and Mikamo, K., Cytogenetics, 9, 116 (1970).
Jerome, H., Cathelineau, L., and Bomsel-Helmreich, O., Proc. Sixth Intern. Cong. Reprod., 2, 893 (1968).
Miller, G., Berlowitz, L., and Regelson, W., Chromosoma, 32, 251 (1971).
Comings, D. E., Lancet, ii, 1137 (1966).
Cattanach, B. M., Pollard, C. E., and Perez, J. N., Genet. Res., 14, 223 (1969).
Hamerton, J. L., Richardson, B. J., Gee, P. A., Allen, W. R., and Short, R. V., Nature, 232, 312 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LYON, M. Possible Mechanisms of X Chromosome Inactivation. Nature New Biology 232, 229–232 (1971). https://doi.org/10.1038/newbio232229a0
Issue Date:
DOI: https://doi.org/10.1038/newbio232229a0
This article is cited by
-
Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution
Nature Communications (2021)
-
The X chromosome in space
Nature Reviews Genetics (2017)
-
X-chromosome inactivation and escape
Journal of Genetics (2015)
-
Chromosomal disorders and male infertility
Asian Journal of Andrology (2012)
-
Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control
Nature Reviews Molecular Cell Biology (2011)
