Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Study
  • Published:

Bilateral metachronous testicular seminoma

Nature Clinical Practice Urology volume 2, pages 457–460 (2005)Cite this article

Abstract

Background A 33-year-old male presented to hospital with a painless right testicular mass measuring 2 × 3 cm and no systemic symptoms. The patient had no relevant medical history. CT and blood tests did not reveal metastasis and the patient was treated with a right inguinal orchiectomy and radiotherapy. After 4 years a routine follow-up examination revealed a 1 cm palpable mass in the left testis.

Investigations CT, tumor marker assessment, scrotal ultrasonography, Doppler ultrasound examination, and biopsy.

Diagnosis Bilateral metachronous testicular seminoma, stage pT1N0M0S0.

Management Radiotherapy, radical orchiectomy, bilateral placement of testicular prostheses, androgen substitution therapy, regular follow-up assessment.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Pollock RE et al. (2005) UICC Manual of Clinical Oncology, Edn 8. Hoboken: Wiley

    Google Scholar 

  2. Che M et al. (2002) Bilateral testicular germ cell tumors. Twenty-year experience at M.D. Anderson Cancer Center. Cancer 95: 1228–1233

    Article  Google Scholar 

  3. Patel RS et al. (1990) Synchronous and metachronous bilateral testicular tumors. Mayo Clinic experience. Cancer 65: 1–4

    Article  CAS  Google Scholar 

  4. Géczi et al. (2003) The incidence, prognosis, clinical and histological characteristics, treatment, and outcome of patients with bilateral germ cell testicular cancer in Hungary. J Cancer Res Clin Oncol 129: 309–315

    PubMed  Google Scholar 

  5. Holzbeierlein JM et al. (2003) Histology and clinical outcomes in patients with bilateral testicular germ cell tumors: the Memorial Sloan Kettering Cancer Center experience 1950 to 2001. J Urol 169: 2122–2125

    Article  Google Scholar 

  6. Ondruš D et al. (2001) Bilateral testicular germ-cell tumors—a single centre long-term experience. Int Urol Nephrol 33: 521–524

    Article  Google Scholar 

  7. Osterlind A et al. (1991) Risk of bilateral testicular germ cell cancer in Denmark: 1960–1984. J Natl Cancer Inst 83: 1391–1395

    Article  CAS  Google Scholar 

  8. Hindley RG et al. (2003) Impalpable testis cancer. BJU Int 92: 572–574

    Article  CAS  Google Scholar 

  9. Kim B et al. (2003) Testicular microlithiasis: clinical significance and review of the literature. Eur Radiol 13: 2567–2576

    Article  Google Scholar 

  10. Rashid HH et al. (2004) Testicular microlithiasis: a review and its association with testicular cancer. Urol Oncol 22: 285–289

    Article  Google Scholar 

  11. Alsikafi NF et al. (1998) Bilateral metachronous testicular seminoma associated with microlithiasis. J Urol 159: 1643–1644

    Article  CAS  Google Scholar 

  12. Wang C et al. (2004) Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab 89: 2085–2098

    Article  CAS  Google Scholar 

  13. Heidenreich A et al. (1995) A conservative approach to bilateral testicular germ cell tumors. J Urol 253: 10–13

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Assistant Professor in the Department of Urology, Faculty of Medicine, at the University of Trakya, Edirne, Turkey

    Mustafa Kaplan

  2. Head of the Section of Urologic Oncology at the Glickman Urological Institute, Professor of Surgery at the Cleveland Clinic Lerner College of Medicine at the Cleveland Clinic Foundation, and co-Director of the Genitourinary Malignancies Program at the Case Comprehensive Cancer Center, Cleveland, OH, USA

    Eric A Klein

Authors
  1. Mustafa Kaplan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eric A Klein
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eric A Klein.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaplan, M., Klein, E. Bilateral metachronous testicular seminoma. Nat Rev Urol 2, 457–460 (2005). https://doi.org/10.1038/ncpuro0295

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpuro0295

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing