Review Article | Published:

In silico cancer modeling: is it ready for prime time?

Nature Clinical Practice Oncology volume 6, pages 3442 (2009) | Download Citation

Subjects

Abstract

At the dawn of the era of personalized, systems-driven medicine, computational or in silico modeling and the simulation of disease processes is becoming increasingly important for hypothesis generation and data integration in both experiments and clinics alike. Arguably, the use of these techniques is nowhere more visible than in oncology. To illustrate the field's vast potential, as well as its current limitations, we briefly review selected studies on modeling malignant brain tumors. Implications for clinical practice, and for clinical trial design and outcome prediction, are also discussed.

Key points

  • In generating experimentally testable hypotheses and facilitating multimodality data integration, in silico modeling is a driving force behind cancer systems biology

  • As exemplified by reviewing selected works on malignant brain tumors, practical applications for computational and mathematical cancer modeling reach from simulating aspects of tumor initiation and progression to modeling of treatment effect

  • In silico modeling is a tool geared to aiding experimental researchers and physicians in investigating the complex processes involved in tumorigenesis, thus supporting innovative discovery research and accelerating the identification of promising targets

  • Although there is no single simulator platform that fits all needs, discrete–continuum (hybrid) modeling, especially agent-based approaches, is particularly promising in integrating molecular, microscopic and macroscopic oncology data and in analyzing processes across scales in space and time

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Acknowledgements

This work has been supported, in part, by NIH grants CA 085139 and CA 113004 (CViT; https://www.cvit.org) and by the Harvard-MIT (HST) Athinoula A Martinos Center for Biomedical Imaging and the Department of Radiology at Massachusetts General Hospital.

Author information

Affiliations

  1. TS Deisboeck is Assistant Professor of Radiology and J Yoon is a Postdoctoral Research Fellow at the Complex Biosystems Modeling Laboratory, Harvard-MIT (HST) Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA,

    • Thomas S Deisboeck
    • , Le Zhang
    • , Jeongah Yoon
    •  & Jose Costa
  2. L Zhang is Assistant Professor, Department of Mathematical Sciences, Michigan Technological University, Houghton, MI, USA, and

  3. J Costa is Professor of Pathology and Medicine (Oncology), Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Thomas S Deisboeck.

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DOI

https://doi.org/10.1038/ncponc1237