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Does prophylactic surgery reduce the risk of gynecologic cancers arising from the Lynch syndrome?

Nature Clinical Practice Oncology volume 3, pages 426–427 (2006)Cite this article

boxed-textSchmeler KM et al. (2006) Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome. N Engl J Med 354: 261–269

Prophylactic gynecologic surgery reduces the risk of endometrial and ovarian cancer in women with Lynch syndrome, but the impact on cancer-related mortality and the risk-benefit ratio remains unclear

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References

  1. Aarnio M et al. (1999) Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer 81: 214–218

    Article  CAS  Google Scholar 

  2. Domchek SM et al. (2006) Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study. Lancet Oncol 7: 223–229

    Article  CAS  Google Scholar 

  3. National Comprehensive Cancer Network (NCCN) Practice Guidelines in Oncology–v.1.2006 [http://www.nccn.org/professionals/physician_gls/PDF/ colorectal_screening.pdf] (accessed 11 May 2006)

  4. Klaren HM et al. (2003) Potential for bias in studies on efficacy of prophylactic surgery for BRCA1 and BRCA2 mutation. J Natl Cancer Inst 95: 941–947

    Article  Google Scholar 

  5. Madalinska JB et al. (2005) Quality-of-life effects of prophylactic salpingo-oophorectomy versus gynecologic screening among women at increased risk of hereditary ovarian cancer. J Clin Oncol 23: 6890–6898

    Article  Google Scholar 

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Acknowledgements

The synopsis was written by Petra Roberts, Associate Editor, Nature Clinical Practice.

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Authors and Affiliations

  1. senior fellow in Hematology-Oncology,

    Deepa S Subramaniam & Claudine Isaacs

  2. Associate Professor of Medicine and Oncology and Director of the Cancer Assessment and Risk Evaluation Program at the Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA

    Deepa S Subramaniam & Claudine Isaacs

Authors
  1. Deepa S Subramaniam
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  2. Claudine Isaacs
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Correspondence to Claudine Isaacs.

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The authors declare no competing financial interests.

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Subramaniam, D., Isaacs, C. Does prophylactic surgery reduce the risk of gynecologic cancers arising from the Lynch syndrome?. Nat Rev Clin Oncol 3, 426–427 (2006). https://doi.org/10.1038/ncponc0562

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  • DOI: https://doi.org/10.1038/ncponc0562

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