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Is fecal DNA testing superior to fecal occult-blood testing for colorectal cancer screening?

Nature Clinical Practice Oncology volume 2, pages 234–235 (2005)Cite this article

boxed-textImperiale TF et al. (2004) Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population. N Engl J Med 351: 2704–2714

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References

  1. Osborn NK and Ahlquist DA (2005) Stool screening for colorectal cancer: molecular approaches. Gastroenterology 128: 192–206

    Article  CAS  Google Scholar 

  2. Tagore K et al. (2003) Sensitivity and specificity of a stool DNA multitarget assay panel for the detection of advanced colorectal neoplasia. Clin Colorectal Cancer 3: 47–53

    Article  CAS  Google Scholar 

  3. Ahlquist DA et al. (1993) Accuracy of fecal occult blood screening for colorectal neoplasia: a prospective study using Hemoccult and HemoQuant tests. JAMA 269: 1262–1267

    Article  CAS  Google Scholar 

  4. Song K et al. (2004) Fecal DNA testing compared with conventional colorectal cancer screening methods: a decision analysis. Gastroenterology 126: 1270–1279

    Article  Google Scholar 

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Acknowledgements

The synopsis was written by Petra Roberts, Associate Editor, Nature Clinical Practice.

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  1. Head of the Translational Research Laboratory at the Institut Catalá d'Oncologia, Barcelona, Spain

    Gabriel Capellá

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  1. Gabriel Capellá
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Correspondence to Gabriel Capellá.

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The author declares no competing financial interests.

Glossary

SENSITIVITY

The likelihood that a test is positive in the presence of disease

TNM STAGE

Tumor-node-metastasis stage

SPECIFICITY

The likelihood that a test is negative in the absence of disease

FECAL MARKER

Any type of molecule leaked (i.e. hemoglobin), secreted or exfoliated (i.e. cells, DNA) that can be recovered, detected and analyzed in stools

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Capellá, G. Is fecal DNA testing superior to fecal occult-blood testing for colorectal cancer screening?. Nat Rev Clin Oncol 2, 234–235 (2005). https://doi.org/10.1038/ncponc0170

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