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Withdrawing antiepileptic drugs in seizure-free patients: what are the cognitive benefits?

Nature Clinical Practice Neurology volume 3, pages 194–195 (2007)Cite this article

boxed-textHessen E et al. (2006) Influence of major antiepileptic drugs on attention, reaction time, and speed of information processing: results from a randomized, double-blind, placebo-controlled withdrawal study of seizure-free epilepsy patients receiving monotherapy. Epilepsia 47: 2038–2045

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References

  1. Ortinski P and Meador KJ (2004) Cognitive side effects of antiepileptic drugs. Epilepsy Behav 5 (Suppl 1): S60–S65

    Article  Google Scholar 

  2. Cochrane HC et al. (1998) Neuropsychological outcomes in randomized controlled trials of antiepileptic drugs: a systematic review of methodology and reporting standards. Epilepsia 30: 1088–1097

    Article  Google Scholar 

  3. Chadwick D and Privitera M (2006) How skeptical should we be about industry-sponsored studies? Neurology 67: 378–379

    Article  Google Scholar 

  4. Sillanpaa A and Schmidt D (2006) Prognosis of seizure recurrence after stopping antiepileptic drugs in seizure-free patients: a long-term population based study of childhood-onset epilepsy. Epilepsy Behav 8: 713–719

    Article  CAS  Google Scholar 

  5. Specchio LM and Beghi E (2004) Should antiepileptic drugs be withdrawn in seizure-free patients? Drugs 18: 201–212

    CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Martina Habeck, Associate Editor, Nature Clinical Practice.

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Author notes

  1. Institute of Neurology, IRCCS C Mondino Foundation and Clinical Pharmacology Unit, University of Pavia, Piazza Botta 10, 27100 Pavia, Italy perucca@unipv.it

Authors and Affiliations

  1. E Perucca is Professor of Clinical Pharmacology and Director of the Laboratories for Diagnostics and Applied Biological Research at the IRCCS C Mondino Foundation, Pavia, Italy.,

    Emilio Perucca

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  1. Emilio Perucca
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Competing interests

The author has received speaker’s or consultancy fees and/or research grants from the manufacturers of carbamazepine and oxcarbazepine (Novartis), gabapentin, phenytoin and pregabalin (Pfizer), lamotrigine (GSK), levetiracetam (UCB Pharma), tiagabine, valproic acid and vigabatrin (sanovi-aventis), topiramate (Johnson & Johnson) and zonisamide (Eisai).

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Perucca, E. Withdrawing antiepileptic drugs in seizure-free patients: what are the cognitive benefits?. Nat Rev Neurol 3, 194–195 (2007). https://doi.org/10.1038/ncpneuro0449

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