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Does trastuzumab increase the risk of isolated CNS metastases in patients with breast cancer?

Nature Clinical Practice Neurology volume 2, pages 302–303 (2006)Cite this article

boxed-textBurstein HJ et al. (2005) Isolated central nervous system metastases in patients with HER2-overexpressing advanced breast cancer treated with first-line trastuzumab-based therapy. Ann Oncol 16: 1772–1777

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References

  1. Clayton AJ et al. (2004) Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer. Br J Cancer 91: 639–643

    Article  CAS  Google Scholar 

  2. Bendell JC et al. (2003) Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer 97: 2972–2977

    Article  Google Scholar 

  3. Lai R et al. (2004) The risk of central nervous system metastases after trastuzumab therapy in patients with breast carcinoma. Cancer 101: 810–816

    Article  CAS  Google Scholar 

  4. Lower EE et al. (2003) Increased rate of brain metastases with trastuzumab therapy not associated with impaired survival. Clin Breast Cancer 4: 114–119

    Article  CAS  Google Scholar 

  5. Miller KD et al. (2003) Occult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survival. Ann Oncol 14: 1072–1077

    Article  CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Petra Roberts, Associate Editor, Nature Clinical Practice.

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Authors and Affiliations

  1. Associate Attending Neurologist and the Director of Clinical Research in the Department of Neurology at Memorial Sloan–Kettering Cancer Center, New York, NY, USA

    Lauren E Abrey

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  1. Lauren E Abrey
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Correspondence to Lauren E Abrey.

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The author declares no competing financial interests.

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Abrey, L. Does trastuzumab increase the risk of isolated CNS metastases in patients with breast cancer?. Nat Rev Neurol 2, 302–303 (2006). https://doi.org/10.1038/ncpneuro0177

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