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Should neutralizing antibodies be monitored during interferon-β treatment for multiple sclerosis?

Nature Clinical Practice Neurology volume 2, pages 76–77 (2006)Cite this article

boxed-textSorensen PS et al. (2005) Appearance and disappearance of neutralizing antibodies during interferon-beta therapy. Neurology 65: 33–39

Antibodies to interferon arise in treated MS patients; these antibodies have clinical implications and the most opportune time to measure them is between 12 and 24 months

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References

  1. Giovannoni G et al. (2002) Neutralising antibodies to interferon beta during the treatment of multiple sclerosis. J Neurol Neurosurg Psychiatry 73: 465–469

    Article  CAS  Google Scholar 

  2. The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group (1996) Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: experience during the first three years. Neurology 47: 889–894

  3. PRISMS (Prevention of Relapses and Disability by Interferon-β-1a Subcutaneously in Multiple Sclerosis) Study Group and the University of British Columbia MS/MRI Analysis Group (2001) PRISMS-4: long-term efficacy of interferon-β-1a in relapsing MS. Neurology 56: 1628–1636

  4. Francis GS et al. (2005) Interferon β-1a in MS: results following development of neutralizing antibodies in PRISMS. Neurology 65: 48–55

    Article  CAS  Google Scholar 

  5. Panitch H et al. (2005) Benefits of high-dose, high-frequency interferon beta-1a in relapsing-remitting multiple sclerosis are sustained to 16 months: final comparative results of the EVIDENCE trial. J Neurol Sci 239: 67–74

    Article  CAS  Google Scholar 

  6. Rice GPB et al. (1999) The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon beta-1b. Neurology 52: 1277–1279

    Article  CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Carol Lovegrove, Freelance Medical Writer.

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Authors and Affiliations

  1. Division of Neurology, the Department of Pathology and the Division of Neurosciences,

    Joel Oger & Ebrima Gibbs

  2. Director of the MS Clinic and the MS Clinical trial group,

    Joel Oger & Ebrima Gibbs

  3. University of British Columbia, Vancouver, Canada

    Joel Oger & Ebrima Gibbs

Authors
  1. Joel Oger
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  2. Ebrima Gibbs
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Correspondence to Joel Oger.

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The authors declare no competing financial interests.

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Cite this article

Oger, J., Gibbs, E. Should neutralizing antibodies be monitored during interferon-β treatment for multiple sclerosis?. Nat Rev Neurol 2, 76–77 (2006). https://doi.org/10.1038/ncpneuro0098

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  • DOI: https://doi.org/10.1038/ncpneuro0098

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