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Does flow cytometry crossmatch predict renal allograft outcome in patients with a negative antiglobulin crossmatch?

Nature Clinical Practice Nephrology volume 3, pages 136–137 (2007)Cite this article

boxed-textWen R et al. (2006) Biomarkers in transplantation: prospective, blinded measurement of predictive value for the flow cytometry crossmatch after negative antiglobulin crossmatch in kidney transplantation. Kidney Int 70: 1474–1481

The capacity of sensitive crossmatch tests to predict outcomes of kidney transplantation remains controversial; however, new tools for identifying anti-HLA antibodies provide a means to resolve this issue

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References

  1. Cecka JM et al. (2005) Preformed cytotoxic antibodies in potential allograft recipients: recent data. Hum Immunol 66: 343–349

    Article  CAS  Google Scholar 

  2. Gebel HM et al. (2003). Pretransplant assessment of donor-reactive, HLA-specific antibodies in renal transplantation: contraindication vs risk. Am J Transplant 3: 1488–1500

    Article  Google Scholar 

  3. Karpinski M et al. (2001) Flow cytometric crossmatching in primary renal transplant recipients with a negative anti-human globulin enhanced cytotoxicity crossmatch. J Am Soc Nephrol 12: 2807–2814

    CAS  PubMed  Google Scholar 

  4. Dmitrienko S et al. (2006) Sensitivity, specificity and predictive value of class I and class II anti-HLA antibodies detected by Luminex in patients undergoing renal transplantation [abstract 10-P]. Hum Immunol 67 (Suppl 1): S114

    Article  Google Scholar 

  5. El-Awar N et al. (2005) HLA antibody identification with single antigen beads compared to conventional methods. Hum Immunol 66: 989–997

    Article  CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Chloë Harman, Associate Editor, Nature Clinical Practice.

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  1. UCLA Immunogenetics Center, 1000 Veteran Avenue 15–20, Los Angeles, CA 90095, USA mcecka@ucla.edu

Authors and Affiliations

  1. JM Cecka is Director of Clinical Research at the Immunogenetics Center of the University of California Los Angeles, CA, USA.,

    J Michael Cecka

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Cecka, J. Does flow cytometry crossmatch predict renal allograft outcome in patients with a negative antiglobulin crossmatch?. Nat Rev Nephrol 3, 136–137 (2007). https://doi.org/10.1038/ncpneph0405

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