Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Methods of stem cell delivery in cardiac diseases

Nature Clinical Practice Cardiovascular Medicine volume 3, pages S110–S113 (2006)Cite this article

Abstract

There are several strategies for cell delivery in cardiac stem cell therapy. The cells can be delivered through coronary arteries, coronary veins, or peripheral veins. Alternatively, direct intramyocardial injection can be performed, using a surgical, transendocardial, or transvenous approach. In this article, we describe the most important conceptual aspects and the evidence for the use of these techniques, with emphasis on intramyocardial injections.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Leone AM et al. (2005) Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J 26: 1196–1204

    Article  Google Scholar 

  2. Shintani S et al. (2001) Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation 103: 2776–2779

    Article  CAS  Google Scholar 

  3. Wang Y et al. (2005) Effect of mobilization of bone marrow stem cells by granulocyte colony stimulating factor on clinical symptoms, left ventricular perfusion and function in patients with severe chronic ischemic heart disease. Int J Cardiol 100: 477–483

    Article  Google Scholar 

  4. Wollert KC et al. (2004) Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST randomized controlled clinical trail. Lancet 364: 141–148

    Article  Google Scholar 

  5. Kocher AA et al. (2001) Neovascularization of ischemic myocardium by human bone-marrow derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 7: 430–436

    Article  CAS  Google Scholar 

  6. Gao J et al. (2001) The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion. Cells Tissues Organs 169: 12–20

    Article  CAS  Google Scholar 

  7. Thompson CA et al. (2003) Percutaneous transvenous cellular cardiomyoplasty. A novel nonsurgical approach for myocardial cell transplantation. J Am Coll Cardiol 41: 1964–1971

    Article  Google Scholar 

  8. Fernández-Avilés F et al. (2004) Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res 95: 742–748

    Article  Google Scholar 

  9. Siminiak T et al. (2003) Autologous bone marrow stem cell transplantation in acute myocardial infarction—report on two cases. Kardiol Pol 59: 502–510

    PubMed  Google Scholar 

  10. Assmus B et al. (2002) Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation 106: 3009–3017

    Article  Google Scholar 

  11. Strauer BE et al. (2001) Intracoronary, human autologous stem cell transplantation for myocardial regeneration following myocardial infarction [in German]. Dtsch Med Wochenschr 126: 932–938

    Article  CAS  Google Scholar 

  12. Herreros J et al. (2003) Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction. Eur Heart J 24: 2012–2020

    Article  Google Scholar 

  13. Dib N et al. (2005) Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four-year follow-up. Circulation 112: 1748–1755

    Article  Google Scholar 

  14. Siminiak T et al. (2004) Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury: phase I clinical study with 12 months of follow-up. Am Heart J 148: 531–537

    Article  Google Scholar 

  15. Pagani FD et al. (2003) Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J Am Coll Cardiol 41: 879–888

    Article  Google Scholar 

  16. Thompson CA et al. (2003) Percutaneous transvenous cellular cardiomyoplasty: a novel nonsurgical approach for myocardial cell transplantation. J Am Coll Cardiol 41: 1964–1971

    Article  Google Scholar 

  17. Smits PC et al. (2003) Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up. J Am Coll Cardiol 42: 2063–2069

    Article  Google Scholar 

  18. Perin EC et al. (2003) Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 107: 2294–2302

    Article  Google Scholar 

  19. Kawamoto A et al. (2003) Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia. Circulation 107: 461–468

    Article  Google Scholar 

  20. Amado L et al. (2005) Cardiac repair with intramyocardial injection of allogenic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci USA 102: 11474–11479

    Article  CAS  Google Scholar 

  21. Siminiak T et al. (2004) Percutaneous transvenous transplantation of autologous myoblasts in the treatment of postinfarction heart failure: the POZNAN trial. Eur Heart J 25 (Suppl): 264

    Google Scholar 

  22. Smits P et al. (2002) Efficiency and retention of a percutaneous transendomyocardial injection of VEGF165 by a fluoroscopy guided transendomyocardial injection catheter. In XIVth World Congress of Cardiology. Sydney, NSW

    Google Scholar 

  23. Sherman W et al. (2006) Catheter-based delivery of cells to the heart. Nat Clin Pract Cardiovasc Med 3 (Suppl 1): S57–S64

    Article  Google Scholar 

  24. Opie SR and Dib N (2006) Surgical and catheter delivery of autologous myoblasts in patients with congestive heart failure. Nat Clin Pract Cardiovasc Med 3 (Suppl 1): S42–S45

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Director of New Cardiovascular Interventional Technology in the Department of Adult Cardiology, Texas Heart Institute at St Luke's Episcopal Hospital, Houston, TX, USA

    Emerson C Perin

  2. a Clinical Cardiologist at the Instituto de Ciencias del Corazón (ICICOR), Hospital Clínico de Valladolid, Valladolid, Spain

    Javier López

Authors
  1. Emerson C Perin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Javier López
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Emerson C Perin.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Perin, E., López, J. Methods of stem cell delivery in cardiac diseases. Nat Rev Cardiol 3 (Suppl 1), S110–S113 (2006). https://doi.org/10.1038/ncpcardio0447

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpcardio0447

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing