Abstract
Diversity-oriented synthesis (DOS) is an emerging field involving the synthesis of combinatorial libraries of diverse small molecules for biological screening. Rather than being directed toward a single biological target, DOS libraries can be used to identify new ligands for a variety of targets. Several different strategies for library design have been developed to target the biologically relevant regions of chemical structure space. DOS has provided powerful probes to investigate biological mechanisms and also served as a new driving force for advancing synthetic organic chemistry.
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Acknowledgements
Generous financial support for my laboratory has been provided by the US National Institutes of Health (CA104685), Department of Defense (CM030085), William Randolph Hearst Fund in Experimental Therapeutics, Mr. William H. Goodwin and Mrs. Alice Goodwin and the Commonwealth Foundation for Cancer Research, and the Experimental Therapeutics Center of Memorial Sloan-Kettering Cancer Center.
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Tan, D. Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nat Chem Biol 1, 74–84 (2005). https://doi.org/10.1038/nchembio0705-74
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DOI: https://doi.org/10.1038/nchembio0705-74
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