When introduced into living cells, drugs frequently evoke unanticipated responses that are due either to off-target effects or to previously unknown interactions between the intended target and other biochemical pathways. The development of a panel of high-resolution sentinel assays for signal-transduction cascades in human cells promises to enhance the power of chemical genetics and increase the efficiency of drug-discovery research.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Frantz, S. Nature 437, 942–943 (2005).
Garber, K. Nat. Biotechnol. 24, 127–130 (2006).
MacDonald, M.L. et al. Nat. Chem. Biol. 2, 329–337 (2006).
Remy, I. & Michnick, S.W. Proc. Natl. Acad. Sci. USA 96, 5394–5399 (1999).
Luker, K.E. et al. Proc. Natl. Acad. Sci. USA 101, 12288–12293 (2004).
Piehler, J. Curr. Opin. Struct. Biol. 15, 4–14 (2005).
Kola, I. & Landis, J. Nat. Rev. Drug Discov. 3, 711–715 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Abraham, R. Signalomic signatures enlighten drug profiling. Nat Chem Biol 2, 295–296 (2006). https://doi.org/10.1038/nchembio0606-295
Issue Date:
DOI: https://doi.org/10.1038/nchembio0606-295
