Synthetic biology

Reframing cell therapy for cancer

Technologies for engineering immune cells to recognize features on cancer cells are transforming oncology. Synthetic biologists now expand this approach by conferring therapeutic functions to nonimmune cells and by programming cells to sense and respond to a new class of physiological cues.

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Figure 1: Comparison across frameworks for engineering cells to respond to cancer.

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Correspondence to Joshua N Leonard.

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Dolberg, T., Donahue, P. & Leonard, J. Reframing cell therapy for cancer. Nat Chem Biol 14, 204–205 (2018). https://doi.org/10.1038/nchembio.2573

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