Commentary | Published:

Target class drug discovery

Nature Chemical Biology volume 13, pages 10531056 (2017) | Download Citation

Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complementary approach that has higher quality outcomes in early discovery efforts.

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Author information

Affiliations

  1. Kimberly D. Barnash, Lindsey I. James and Stephen V. Frye are in the Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

    • Kimberly D Barnash
    • , Lindsey I James
    •  & Stephen V Frye

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Stephen V Frye.

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DOI

https://doi.org/10.1038/nchembio.2473

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