25-Hydroxycholesterol induces miR-185 to suppress lipid and cholesterol synthesis pathways and inhibit viruses such as hepatitis C virus (HCV), that use host membranes to propagate. HCV counteracts this by suppressing miR-185 expression to drive increased cellular lipid content.
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Thibault, P., Wilson, J. MicroRNA-lipid one-upmanship. Nat Chem Biol 11, 905–906 (2015). https://doi.org/10.1038/nchembio.1953
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DOI: https://doi.org/10.1038/nchembio.1953
