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Iron-sulfur proteins hiding in plain sight

Recent studies suggest that iron-sulfur (Fe-S) proteins may be unexpectedly abundant and functionally diverse in mammalian cells, but their identification still remains difficult. The use of informatics along with traditional spectroscopic analyses could be key to discovering new Fe-S proteins and validating their functional roles.

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Figure 1: A timeline that illustrates the increasing pace of mammalian Fe-S discovery.
Figure 2: A flow chart for an approach to the identification of new Fe-S proteins.
Figure 3: Pathways in which Fe-S proteins may be critical.

Marina Corral Spence/Nature Publishing Group

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Acknowledgements

I thank G. Holmes-Hampton and W.H. Tong for helpful discussions and G. Holmes-Hampton for generating the tracings in Figure 2.

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Correspondence to Tracey A Rouault.

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Rouault, T. Iron-sulfur proteins hiding in plain sight. Nat Chem Biol 11, 442–445 (2015). https://doi.org/10.1038/nchembio.1843

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