Recent studies suggest that iron-sulfur (Fe-S) proteins may be unexpectedly abundant and functionally diverse in mammalian cells, but their identification still remains difficult. The use of informatics along with traditional spectroscopic analyses could be key to discovering new Fe-S proteins and validating their functional roles.
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Acknowledgements
I thank G. Holmes-Hampton and W.H. Tong for helpful discussions and G. Holmes-Hampton for generating the tracings in Figure 2.
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Rouault, T. Iron-sulfur proteins hiding in plain sight. Nat Chem Biol 11, 442–445 (2015). https://doi.org/10.1038/nchembio.1843
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DOI: https://doi.org/10.1038/nchembio.1843
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