The Doc-Phd pair forms a bacterial toxin-antitoxin system, but the mechanism by which the Fic-family member Doc causes toxicity is not fully defined. New research shows that Doc unexpectedly functions as a kinase to phosphorylate elongation factor TU, thus inhibiting translation and leading to Doc-mediated growth arrest.
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Change history
11 December 2013
In the version of this article initially published, the citation to reference 4 incorrectly referred to 'Castro-Roa, K.'. The correct author's name is 'Castro-Roa, D.'. The error has been corrected in the HTML and PDF versions of the article.
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Peti, W., Page, R. What's up 'Doc'?. Nat Chem Biol 9, 756–757 (2013). https://doi.org/10.1038/nchembio.1379
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DOI: https://doi.org/10.1038/nchembio.1379
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