A major determinant of the ion flux rate through acetylcholine receptors is a ring of five residues, four glutamates and a glutamine, at the channel's cytoplasmic mouth. The glutamates adopt alternate rotamer conformations so that only two directly affect channel conductance.
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Akabas, M. Rotamers affect ion conductance. Nat Chem Biol 8, 953–954 (2012). https://doi.org/10.1038/nchembio.1115
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DOI: https://doi.org/10.1038/nchembio.1115
