A gain of function in the cancer-associated mutant of isocitrate dehydrogenase inspired protein engineering of Saccharomyces cerevisiae homoisocitrate dehydrogenase to create a 2-hydroxyadipate dehydrogenase. This neoactivity yields chirally pure (R)-2-hydroxyadipic acid, a synthetic precursor to the industrially valuable adipic acid used in pharmaceuticals and synthetic polymers.
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Dang, L. A biocatalyst inspired by cancer. Nat Chem Biol 8, 874–875 (2012). https://doi.org/10.1038/nchembio.1090
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DOI: https://doi.org/10.1038/nchembio.1090
