Compression of the active sites of enzymes has been linked to the bulk of amino acid side chains, but now experiments highlight that the harder we look, the more curious the relationship between protein structure and function becomes.
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Klinman, J. Control of active-site compression. Nature Chem 2, 907–909 (2010). https://doi.org/10.1038/nchem.886
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DOI: https://doi.org/10.1038/nchem.886
