Compound 2b

Synthetic procedure: See article for the definitive version of this procedure and for full experimental details.

Dihydroxyacetone (2q; 9 mg, 0.1 mmol) was dissolved in sodium phosphate buffer (pH 7, 1M, 1 mL, H₂O/D₂O 9:1). The conversion of 2q to glyceraldehyde (2b) was monitored at room temperature by ¹H NMR spectroscopy. Multiplet signals corresponding to 2b started to appear after 24 h, with no significant change after 120 h, glyceraldehyde (2b) was present in no more than 10% of the total composition (Supplementary Figure 3). ¹H NMR (300 MHz, H₂O/D₂O 9:1) rac-glyceraldehyde (2b·H₂O): δ 3.63–3.68 (m, 1H, (C2)–H), 3.52–3.56 (m, 2H, (C3)–H), 3.48–3.51 (m, 1H, (C3)–H);

PubChemID:

319901781

MDL Molfile:

41557_2017_BFnchem2703_MOESM24_ESM.mol

ChemDraw:

41557_2017_BFnchem2703_MOESM25_ESM.cdx