Cancer treatments often focus on killing tumour cells through apoptosis, which is thought to typically require mitochondrial outer membrane permeabilization (MOMP) and subsequent caspase activation. A study now shows that MOMP can trigger TNF-dependent, but caspase-independent cell death, suggesting a different approach to improve cancer therapy.
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Caspase-mediated cleavage of the centrosomal proteins during apoptosis
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Fitzwalter, B., Thorburn, A. A caspase-independent way to kill cancer cells. Nat Cell Biol 19, 1014–1015 (2017). https://doi.org/10.1038/ncb3604
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DOI: https://doi.org/10.1038/ncb3604
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Caspase-mediated cleavage of the centrosomal proteins during apoptosis
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