Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS–STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways.
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Change history
30 October 2017
In the original version of this News and Views, the name of author Marina Ruiz de Galarreta was coded wrongly, resulting in it being incorrect when exported to citation databases. This has now been corrected, though no visible changes will be apparent.
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Ruiz de Galarreta, M., Lujambio, A. DNA sensing in senescence. Nat Cell Biol 19, 1008–1009 (2017). https://doi.org/10.1038/ncb3603
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DOI: https://doi.org/10.1038/ncb3603
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