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A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation

Nature Cell Biology volume 19, pages 10121013 (2017) | Download Citation

Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs.

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Author information

Affiliations

  1. Clea Bárcena and Carlos López-Otín are in the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain

    • Clea Bárcena
    •  & Carlos López-Otín

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Carlos López-Otín.

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DOI

https://doi.org/10.1038/ncb3602

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