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Reducing interferon'ce in stem cells

Little is known regarding how the interactions of stem cells with the immune system regulate their plasticity. A study now describes a mechanism by which normal breast and cancer stem cells utilize miR-199a to downregulate the corepressor LCOR and minimize responses to type I interferon.

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Figure 1: Regulation of stemness by controlling cellular responses to type I IFNs through the miR-199a–LCOR axis.

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Correspondence to Brian Ruffell.

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Gardner, A., Ruffell, B. Reducing interferon'ce in stem cells. Nat Cell Biol 19, 597–599 (2017). https://doi.org/10.1038/ncb3544

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