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Terminating the replication helicase

A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state.

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Figure 1: The MCM helicase cycle within the cell cycle.
Figure 2: At least two pathways target terminated CMG complexes in C. elegans.

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Correspondence to Philip Zegerman.

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Gaggioli, V., Zegerman, P. Terminating the replication helicase. Nat Cell Biol 19, 410–412 (2017). https://doi.org/10.1038/ncb3519

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