Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Terminating the replication helicase

A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: The MCM helicase cycle within the cell cycle.
Figure 2: At least two pathways target terminated CMG complexes in C. elegans.


  1. Dewar, J. M., Low, E., Mann, M., Räschle, M. & Walter, J. C. Genes Dev. (2017).

    Google Scholar 

  2. Sonneville, R. et. al. Nat. Cell Biol. 19, 468–479 (2017).

    CAS  Article  Google Scholar 

  3. Arias, E. E. & Walter, J. C. Genes Dev. 21, 497–518 (2007).

    CAS  Article  Google Scholar 

  4. Deegan, T. D. & Diffley, J. F. Curr. Opin. Struct. Biol. 37, 145–151 (2016).

    CAS  Article  Google Scholar 

  5. Moreno, S. P., Bailey, R., Campion, N., Herron, S. & Gambus, A. Science 346, 477–481 (2014).

    Article  Google Scholar 

  6. Maric, M., Maculins, T., De Piccoli, G. & Labib, K. Science 346, 1253596 (2014).

    Article  Google Scholar 

  7. Dantuma, N. P. & Hoppe, T. Trends Cell Biol. 22, 483–491 (2012).

    CAS  Article  Google Scholar 

  8. Dewar, J. M., Budzowska, M. & Walter, J. C. Nature 525, 345–350 (2015).

    CAS  Article  Google Scholar 

  9. Ossareh-Nazari, B., Katsiarimpa, A., Merlet, J. & Pintard, L. G3 (Bethesda) 6, 3431–3442 (2016).

    CAS  Article  Google Scholar 

  10. Franz, A. et al. Nat. Commun. 7, 10612 (2016).

    CAS  Article  Google Scholar 

  11. Weber, G. F. Sarcoma 2015, 839182 (2015).

    Article  Google Scholar 

  12. Diffley, J. F. X., Cocker, J. H., Dowell, S. J. & Rowley, A. Cell 78, 303–316 (1994).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Philip Zegerman.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Gaggioli, V., Zegerman, P. Terminating the replication helicase. Nat Cell Biol 19, 410–412 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing