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Inheritance of protection from osmotic stress

Exposure of mother worms to mild osmotic stress induces gene expression changes in offspring that protect them from strong osmotic stress. Inheritance of protection is now shown to depend on altered insulin-like signalling in the maternal germline, which confers protection through increased expression of zygotic gpdh-2, a rate-limiting enzyme in glycerol biosynthesis.

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Figure 1: Adaptive and maternally inherited larval responses to osmotic stress.

References

  1. 1

    Pembrey, M., Saffery, R. & Bygren, L. O. J. Med. Genet. 51, 563–572 (2014).

    Article  Google Scholar 

  2. 2

    Burton, N. O. et al. Nat. Cell Biol. 19, 252–257 (2017).

    CAS  Article  Google Scholar 

  3. 3

    Frazier, H. N. III & Roth, M. B. Curr. Biol. 19, 859–863 (2009).

    CAS  Article  Google Scholar 

  4. 4

    Murphy, C. T. & Hu, P. J. Insulin/insulin-like Growth Factor Signaling in C. elegans (WormBook, 2013); http://doi.org/bx5j

    Book  Google Scholar 

  5. 5

    Lim, J. P. & Brunet, A. Trends Genet. 29, 176–186 (2013).

    CAS  Article  Google Scholar 

  6. 6

    van Otterdijk, S. D. & Michels, K. B. FASEB J. 30, 2457–2465 (2016).

    CAS  Article  Google Scholar 

  7. 7

    Heard, E. & Martienssen, R. A. Cell 157, 95–109 (2014).

    CAS  Article  Google Scholar 

  8. 8

    Carone, B. R. et al. Cell 143, 1084–1096 (2010).

    CAS  Article  Google Scholar 

  9. 9

    Rando, O. J. Cold Spring Harb. Perspect. Med. 6, a022988 (2016).

    Article  Google Scholar 

  10. 10

    Gaydos, L. J., Wang, W. & Strome, S. Science 345, 1515–1518 (2014).

    CAS  Article  Google Scholar 

  11. 11

    Devanapally, S., Ravikumar, S. & Jose, A. M. Proc. Natl Acad. Sci. USA 112, 2133–2138 (2015).

    CAS  Article  Google Scholar 

  12. 12

    Houri-Zeevi, L. & Rechavi, O. Trends Genet. 33, 46–57 (2017).

    CAS  Article  Google Scholar 

  13. 13

    Zimmet, P. Z., Magliano, D. J., Herman, W. H. & Shaw, J. E. Lancet Diabetes Endocrinol. 2, 56–64 (2014).

    Article  Google Scholar 

  14. 14

    Waki, H., Yamauchi, T. & Kadowaki, T. Curr. Diab. Rep. 12, 673–685 (2012).

    CAS  Article  Google Scholar 

  15. 15

    Pereira, T. J., Moyce, B. L., Kereliuk, S. M. & Dolinsky, V. W. Biochem. Cell Biol. 93, 438–451 (2015).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Susan Strome.

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Kaneshiro, K., Strome, S. Inheritance of protection from osmotic stress. Nat Cell Biol 19, 151–152 (2017). https://doi.org/10.1038/ncb3483

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