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Lnc-ing ROR1–HER3 and Hippo signalling in metastasis

Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1–HER3 and Hippo–YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

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Figure 1: The lncRNA MAYA mediates the cross-talk between the ROR1–HER3 and Hippo pathways to promote bone metastasis.

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Correspondence to Yibin Kang.

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Zhuo, W., Kang, Y. Lnc-ing ROR1–HER3 and Hippo signalling in metastasis. Nat Cell Biol 19, 81–83 (2017). https://doi.org/10.1038/ncb3467

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