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Y chromothripsis?

Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining.

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Figure 1: Model of chromothripsis after Y centromere inactivation and micronucleation.


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Correspondence to Emily M. Hatch.

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Hatch, E. Y chromothripsis?. Nat Cell Biol 19, 12–14 (2017).

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