The endoplasmic reticulum (ER) is the largest membrane-bound organelle in cells, and its size needs to be carefully controlled. Downsizing the ER by autophagy is now shown to involve Sec62, a protein that also helps to build up the organelle. This link suggests a molecular switch for ER size control.
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Schuck, S. On keeping the right ER size. Nat Cell Biol 18, 1118–1119 (2016). https://doi.org/10.1038/ncb3430
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DOI: https://doi.org/10.1038/ncb3430
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