Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Primary cilia mechanosensing triggers autophagy-regulated cell volume control

The primary cilium and the process of autophagy are thought to be in a functionally reciprocal relationship. In further support of this link, fluid flow sensing by the primary cilium is now shown to induce autophagy, which in turn regulates the volume of kidney epithelial cells.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Regulation of the epithelial kidney cell volume is mediated by primary-cilium-dependent autophagy.


  1. 1

    Mizushima, N., Levine, B., Cuervo, A. M. & Klionsky, D. J. Nature 451, 1069–1075 (2008).

    CAS  Article  Google Scholar 

  2. 2

    Fliegauf, M., Benzing, T. & Omran, H. Mol. Cell Biol. 8, 880–893 (2007).

    CAS  Google Scholar 

  3. 3

    Pampliega, O. & Cuervo, A. M. Curr. Opin. Cell Biol. 39, 1–7 (2016).

    CAS  Article  Google Scholar 

  4. 4

    Orhon, I. et al. Nat. Cell Biol. 18, 657–667 (2016).

    CAS  Article  Google Scholar 

  5. 5

    Satir, P., Pedersen, L. B. & Christensen, S. T. J. Cell Sci. 123, 499–503 (2010).

    CAS  Article  Google Scholar 

  6. 6

    Rosenbaum, J. L. & Witman, G. B. Nat. Rev. Mol. Cell Biol. 3, 813–825 (2002).

    CAS  Article  Google Scholar 

  7. 7

    Praetorius, H. A. Am. J Physiol. Cell Physiol. 308, 198–208 (2015).

    Article  Google Scholar 

  8. 8

    Nauli, S. M. et al. Nat. Genet. 33, 129–137 (2003).

    CAS  Article  Google Scholar 

  9. 9

    Kuma, A. et al. Nature 432, 1032–1036 (2004).

    CAS  Article  Google Scholar 

  10. 10

    Meijer, A. J., Lorin, S., Blommaart, E. F. & Codogno, P. Amino Acids 47, 2037–2063 (2015).

    CAS  Article  Google Scholar 

  11. 11

    Pampliega, O. et al. Nature 502, 194–200 (2013).

    CAS  Article  Google Scholar 

  12. 12

    Wang, S., Livingston, M. J., Su, Y. & Dong, Z. Autophagy 11, 607–616 (2015).

    CAS  Article  Google Scholar 

  13. 13

    Boehlke, C. et al. Nat. Cell Biol. 12, 1115–1122 (2010).

    CAS  Article  Google Scholar 

  14. 14

    Patel, A. & Honore, E. Nat. Rev. Nephrol. 6, 530–538 (2010).

    CAS  Article  Google Scholar 

  15. 15

    Martins, I. et al. Cell Death Diff. 21, 79–91 (2014).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Tassula Proikas-Cezanne.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Takacs, Z., Proikas-Cezanne, T. Primary cilia mechanosensing triggers autophagy-regulated cell volume control. Nat Cell Biol 18, 591–592 (2016).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing