The molecular clutch model for mechanotransduction evolves

Many biological processes are influenced by the mechanical rigidity of surrounding tissues. Now, a combination of experiments and mathematical modelling has been used to describe the precise molecular and physical mechanism by which cells sense and respond to the mechanical properties of their extracellular environment through integrin-based adhesions.

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Figure 1: The Roca-Cusachs model of the molecular clutch.

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Correspondence to Clare M. Waterman.

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Swaminathan, V., Waterman, C. The molecular clutch model for mechanotransduction evolves. Nat Cell Biol 18, 459–461 (2016). https://doi.org/10.1038/ncb3350

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