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Directing lipid transport at membrane contact sites

Contact sites between the endoplasmic reticulum and the plasma membrane mediate receptor signalling. How this function is controlled physically and functionally is poorly understood. Extended synaptotagmins are now shown to shuttle the lipid metabolite diacylglycerol from the plasma membrane to the endoplasmic reticulum in receptor-stimulated cells.

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Figure 1: E-Syts promote the transport of DAG at ER–PM contact sites.

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Correspondence to Michael Krauβ or Volker Haucke.

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Krauβ, M., Haucke, V. Directing lipid transport at membrane contact sites. Nat Cell Biol 18, 461–463 (2016). https://doi.org/10.1038/ncb3345

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