Cancer cells are known to secrete exosomes with pro-metastatic effects. Pancreatic-cancer-derived exosomes are now shown to promote liver metastasis by eliciting pre-metastatic niche formation through a multi-step process. This involves uptake of exosome-derived factors by liver Kupffer cells and hepatic stellate cell activation to generate a fibrotic microenvironment with immune cell infiltrates that favours metastasis.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma
Molecular Cancer Open Access 24 July 2023
-
Exosomal MFI2-AS1 sponge miR-107 promotes non-small cell lung cancer progression through NFAT5
Cancer Cell International Open Access 18 March 2023
-
Cervical cancer-derived exosomal miR-663b promotes angiogenesis by inhibiting vinculin expression in vascular endothelial cells
Cancer Cell International Open Access 19 December 2021
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gupta, G. P. & Massague, J. Cell 127, 679–695 (2006).
Chaffer, C. L. & Weinberg, R. A. Science 331, 1559–1564 (2011).
Chambers, A. F., Groom, A. C. & MacDonald, I. C. Nat. Rev. Cancer 2, 563–572 (2002).
Torre, L. A. et al. CA: Cancer J. Clin. 65, 87–108 (2015).
Peinado, H., Lavotshkin, S. & Lyden, D. Semin. Cancer Biol. 21, 139–146 (2011).
Sceneay, J., Smyth, M. J. & Moller, A. Cancer Metast. Rev. 32, 449–464 (2013).
Peinado, H. et al. Nat. Med. 18, 883–891 (2012).
El Andaloussi, S., Mager, I., Breakefield, X. O. & Wood, M. J. Nat. Rev. Drug Discov. 12, 347–357 (2013).
Martins, V. R., Dias, M. S. & Hainaut, P. Curr. Opin. Oncol. 25, 66–75 (2013).
Camussi, G., Deregibus, M. C., Bruno, S., Cantaluppi, V. & Biancone, L. Kidney Int. 78, 838–848 (2010).
Tickner, J. A., Urquhart, A. J., Stephenson, S. A., Richard, D. J. & O'Byrne, K. J. Front. Oncol. 4, 127 (2014).
Costa-Silva, B. et al. Nat. Cell Biol. 17, 816–825 (2015).
Kaplan, R. N. et al. Nature 438, 820–827 (2005).
Funamizu, N. et al. Int. J. Cancer 132, 785–794 (2013).
Rhim, A. D. et al. Cell 148, 349–361 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Zhang, Y., Wang, XF. A niche role for cancer exosomes in metastasis. Nat Cell Biol 17, 709–711 (2015). https://doi.org/10.1038/ncb3181
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3181
This article is cited by
-
Exosomal MFI2-AS1 sponge miR-107 promotes non-small cell lung cancer progression through NFAT5
Cancer Cell International (2023)
-
Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma
Molecular Cancer (2023)
-
N-Glycomic profiling reveals dysregulated glycans related to oral cancer using MALDI-MS
Analytical and Bioanalytical Chemistry (2022)
-
AKR1B1 promotes pancreatic cancer metastasis by regulating lysosome-guided exosome secretion
Nano Research (2022)
-
Cervical cancer-derived exosomal miR-663b promotes angiogenesis by inhibiting vinculin expression in vascular endothelial cells
Cancer Cell International (2021)
